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Question 1
Correct
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A 65-year-old male, who is a known type 2 diabetic, visits his GP for a diabetes check-up. He is currently taking metformin and his GP has prescribed a sulphonylurea to improve his blood sugar management. What is the mode of action of this medication?
Your Answer: Closes potassium-ATP channels on the beta cells
Explanation:Sulfonylureas bind to potassium-ATP channels on the cell membrane of pancreatic beta cells, mimicking the role of ATP from the outside. This results in the blocking of these channels, causing membrane depolarisation and the opening of voltage-gated calcium channels. As a result, insulin release is stimulated.
While acute use of sulfonylureas increases insulin secretion and decreases insulin clearance in the liver, it can also cause hypoglycaemia, which is the main side effect. This can lead to the serious complication of neuroglycopenia, resulting in a lack of glucose supply to the brain, causing confusion and possible coma. Treatment for this should involve oral glucose, intramuscular glucagon, or intravenous glucose.
Chronic exposure to sulfonylureas does not result in an acute increase in insulin release, but a decrease in plasma glucose concentration does remain. Additionally, chronic exposure to sulfonylureas leads to down-regulation of their receptors.
Sulfonylureas are a type of medication used to treat type 2 diabetes mellitus. They work by increasing the amount of insulin produced by the pancreas, but only if the beta cells in the pancreas are functioning properly. Sulfonylureas bind to a specific channel on the cell membrane of pancreatic beta cells, known as the ATP-dependent K+ channel (KATP).
While sulfonylureas can be effective in managing diabetes, they can also cause some adverse effects. The most common side effect is hypoglycemia, which is more likely to occur with long-acting preparations like chlorpropamide. Another common side effect is weight gain. However, there are also rarer side effects that can occur, such as hyponatremia (low sodium levels) due to inappropriate ADH secretion, bone marrow suppression, hepatotoxicity (liver damage), and peripheral neuropathy.
It is important to note that sulfonylureas should not be used during pregnancy or while breastfeeding.
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This question is part of the following fields:
- Endocrine System
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Question 2
Incorrect
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What is the half life of insulin in the circulation of a typical healthy adult?
Your Answer: Between 2 and 3 hours
Correct Answer: Less than 30 minutes
Explanation:Enzymes in the bloodstream break down insulin, resulting in a half-life of under 30 minutes. In type 2 diabetes, there may be irregularities in the insulin clearance process.
Insulin is a hormone produced by the pancreas that plays a crucial role in regulating the metabolism of carbohydrates and fats in the body. It works by causing cells in the liver, muscles, and fat tissue to absorb glucose from the bloodstream, which is then stored as glycogen in the liver and muscles or as triglycerides in fat cells. The human insulin protein is made up of 51 amino acids and is a dimer of an A-chain and a B-chain linked together by disulfide bonds. Pro-insulin is first formed in the rough endoplasmic reticulum of pancreatic beta cells and then cleaved to form insulin and C-peptide. Insulin is stored in secretory granules and released in response to high levels of glucose in the blood. In addition to its role in glucose metabolism, insulin also inhibits lipolysis, reduces muscle protein loss, and increases cellular uptake of potassium through stimulation of the Na+/K+ ATPase pump.
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This question is part of the following fields:
- Endocrine System
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Question 3
Correct
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A 65-year-old woman with hypocalcaemia has elevated parathyroid hormone levels. Is it a typical physiological response to increase calcium levels? In the kidney, where does parathyroid hormone act to enhance calcium reabsorption?
Your Answer: Distal convoluted tubule
Explanation:Understanding Parathyroid Hormone and Its Effects
Parathyroid hormone is a hormone produced by the chief cells of the parathyroid glands. Its main function is to increase the concentration of calcium in the blood by stimulating the PTH receptors in the kidney and bone. This hormone has a short half-life of only 4 minutes.
The effects of parathyroid hormone are mainly seen in the bone, kidney, and intestine. In the bone, PTH binds to osteoblasts, which then signal to osteoclasts to resorb bone and release calcium. In the kidney, PTH promotes the active reabsorption of calcium and magnesium from the distal convoluted tubule, while decreasing the reabsorption of phosphate. In the intestine, PTH indirectly increases calcium absorption by increasing the activation of vitamin D, which in turn increases calcium absorption.
Overall, understanding the role of parathyroid hormone is important in maintaining proper calcium levels in the body. Any imbalances in PTH secretion can lead to various disorders such as hyperparathyroidism or hypoparathyroidism.
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This question is part of the following fields:
- Endocrine System
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Question 4
Correct
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A 42-year-old woman visits her GP complaining of chest pain. She has a history of hypertension and is currently taking metformin for diabetes. The GP observes that her BMI is 45. What is a possible complication of the metabolic syndrome in this case?
Your Answer: Ischemic stroke
Explanation:Metabolic syndrome is a group of risk factors for cardiovascular disease that are caused by insulin resistance and central obesity.
Obesity is associated with higher rates of illness and death, as well as decreased productivity and functioning, increased healthcare expenses, and social and economic discrimination.
The consequences of obesity include strokes, type 2 diabetes, heart disease, certain cancers (such as breast, colon, and endometrial), polycystic ovarian syndrome, obstructive sleep apnea, fatty liver, gallstones, and mental health issues.
The Physiology of Obesity: Leptin and Ghrelin
Leptin is a hormone produced by adipose tissue that plays a crucial role in regulating body weight. It acts on the hypothalamus, specifically on the satiety centers, to decrease appetite and induce feelings of fullness. In cases of obesity, where there is an excess of adipose tissue, leptin levels are high. Leptin also stimulates the release of melanocyte-stimulating hormone (MSH) and corticotrophin-releasing hormone (CRH), which further contribute to the regulation of appetite. On the other hand, low levels of leptin stimulate the release of neuropeptide Y (NPY), which increases appetite.
Ghrelin, on the other hand, is a hormone that stimulates hunger. It is mainly produced by the P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas. Ghrelin levels increase before meals, signaling the body to prepare for food intake, and decrease after meals, indicating that the body has received enough nutrients.
In summary, the balance between leptin and ghrelin plays a crucial role in regulating appetite and body weight. In cases of obesity, there is an imbalance in this system, with high levels of leptin and potentially disrupted ghrelin signaling, leading to increased appetite and weight gain.
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This question is part of the following fields:
- Endocrine System
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Question 5
Correct
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A 50-year-old man visits his GP with concerns about weight gain, decreased energy, low libido, and difficulty maintaining erections. The doctor orders a blood test to check his serum testosterone levels. What is responsible for stimulating testosterone secretion in the body?
Your Answer: Luteinising Hormone
Explanation:Understanding Androgens and Male Hormones
Androgens are the primary male sex hormones that play a crucial role in the development and functioning of reproductive organs and secondary sex characteristics. Testosterone is the main androgen, while dihydrotestosterone and androstenedione are other types. These hormones are also essential in maintaining bone density and mass to prevent osteoporosis.
The regulation of hormone levels in the body relies on negative feedback. Luteinising hormone (LH) stimulates the Leydig cells in the testes to produce testosterone, which is synthesized from cholesterol. When testosterone levels are high, LH is suppressed through negative feedback. A small amount of testosterone is also produced in the adrenal glands.
Other important male hormones include follicle-stimulating hormone (FSH) and dihydrotestosterone (DHT). DHT and testosterone bind to the same androgen receptors, contributing to the development of external genitalia in the fetus, secondary sex characteristics during puberty, and sperm production. DHT is a form of endogenous testosterone converted by the enzyme 5 alpha-reductase in the prostate.
FSH and testosterone work together to stimulate the Sertoli cells in the testes to secrete androgen-binding protein, which binds to testosterone to maintain high levels. Androgen-binding protein is secreted into the lumen of the seminiferous tubules and interstitial fluid around spermatogenic cells. Once the required level of spermatogenesis is achieved, inhibin prevents the release of more FSH.
In summary, understanding the role of androgens and male hormones is crucial in comprehending male reproductive health and development.
Disorders of sex hormones can have various effects on the body, as shown in the table below. Primary hypogonadism, also known as Klinefelter’s syndrome, is characterized by high levels of gonadotrophins and low levels of testosterone. Patients with this condition often have small, firm testes, lack secondary sexual characteristics, and are infertile. They may also experience gynaecomastia, which increases their risk of breast cancer. Diagnosis is made through chromosomal analysis.
Hypogonadotrophic hypogonadism, or Kallmann syndrome, is a cause of delayed puberty due to low levels of sex hormones. It is usually inherited as an X-linked recessive trait and is caused by the failure of GnRH-secreting neurons to migrate to the hypothalamus. Patients with this condition may have hypogonadism, cryptorchidism, anosmia, and low sex hormone levels. However, their LH and FSH levels are inappropriately low or normal. They are typically of normal or above-average height, but may also have cleft lip/palate and visual/hearing defects.
Androgen insensitivity syndrome is an X-linked recessive condition that causes end-organ resistance to testosterone, resulting in genotypically male children (46XY) having a female phenotype. This condition is also known as complete androgen insensitivity syndrome or testicular feminisation syndrome. Patients with this condition may experience primary amenorrhoea, undescended testes causing groin swellings, and breast development due to the conversion of testosterone to oestradiol. Diagnosis is made through a buccal smear or chromosomal analysis to reveal a 46XY genotype. Management involves counselling to raise the child as female, bilateral orchidectomy to reduce the risk of testicular cancer due to undescended testes, and oestrogen therapy.
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This question is part of the following fields:
- Endocrine System
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Question 6
Correct
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A 32-year-old female patient visits your clinic complaining of fatigue and unexplained weight gain. She mentions feeling extremely sensitive to cold temperatures. You suspect hypothyroidism and decide to conduct a test on her serum levels of thyroid stimulating hormone (TSH) and free thyroxine (T4). Which of the following hormones is not secreted from the anterior pituitary gland, where TSH is released?
Your Answer: antidiuretic hormone
Explanation:The hormone ADH (also known as vasopressin) is secreted by the posterior pituitary gland and acts in the collecting ducts of the kidneys to increase water reabsorption. Unlike ADH, all of the other hormone options presented are released from the anterior pituitary. ACTH is a component of the hypothalamic-pituitary-axis and increases the production and release of cortisol from the adrenal gland. GH (also called somatotropin) is an anabolic hormone that stimulates growth in childhood and has metabolic effects on protein, glucose, and lipids. FSH is a gonadotropin that promotes the maturation of germ cells.
Thyroid disorders are commonly encountered in clinical practice, with hypothyroidism and thyrotoxicosis being the most prevalent. Women are ten times more likely to develop these conditions than men. The thyroid gland is a bi-lobed structure located in the anterior neck and is part of a hypothalamus-pituitary-end organ system that regulates the production of thyroxine and triiodothyronine hormones. These hormones help regulate energy sources, protein synthesis, and the body’s sensitivity to other hormones. Hypothyroidism can be primary or secondary, while thyrotoxicosis is mostly primary. Autoimmunity is the leading cause of thyroid problems in the developed world.
Thyroid disorders can present in various ways, with symptoms often being the opposite depending on whether the thyroid gland is under or overactive. For example, hypothyroidism may result in weight gain, while thyrotoxicosis leads to weight loss. Thyroid function tests are the primary investigation for diagnosing thyroid disorders. These tests primarily look at serum TSH and T4 levels, with T3 being measured in specific cases. TSH levels are more sensitive than T4 levels for monitoring patients with existing thyroid problems.
Treatment for thyroid disorders depends on the cause. Patients with hypothyroidism are given levothyroxine to replace the underlying deficiency. Patients with thyrotoxicosis may be treated with propranolol to control symptoms such as tremors, carbimazole to reduce thyroid hormone production, or radioiodine treatment.
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This question is part of the following fields:
- Endocrine System
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Question 7
Correct
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A young man presents with polyuria, polydipsia and weight loss. He is subsequently diagnosed with type 1 diabetes mellitus. What is he at an increased risk of developing?
Your Answer: Addison's disease, Grave's disease, coeliac disease
Explanation:Type 1 diabetes is linked to other autoimmune disorders like Addison’s disease, Grave’s disease, and coeliac disease, due to its own autoimmune nature. The other choices are incorrect as they contain a non-autoimmune disorder.
Understanding Diabetes Mellitus: A Basic Overview
Diabetes mellitus is a chronic condition characterized by abnormally raised levels of blood glucose. It is one of the most common conditions encountered in clinical practice and represents a significant burden on the health systems of the developed world. The management of diabetes mellitus is crucial as untreated type 1 diabetes would usually result in death. Poorly treated type 1 diabetes mellitus can still result in significant morbidity and mortality. The main focus of diabetes management now is reducing the incidence of macrovascular and microvascular complications.
There are different types of diabetes mellitus, including type 1 diabetes mellitus, type 2 diabetes mellitus, prediabetes, gestational diabetes, maturity onset diabetes of the young, latent autoimmune diabetes of adults, and other types. The presentation of diabetes mellitus depends on the type, with type 1 diabetes mellitus often presenting with weight loss, polydipsia, polyuria, and diabetic ketoacidosis. On the other hand, type 2 diabetes mellitus is often picked up incidentally on routine blood tests and presents with polydipsia and polyuria.
There are four main ways to check blood glucose, including a finger-prick bedside glucose monitor, a one-off blood glucose, a HbA1c, and a glucose tolerance test. The diagnostic criteria are determined by WHO, with a fasting glucose greater than or equal to 7.0 mmol/l and random glucose greater than or equal to 11.1 mmol/l being diagnostic of diabetes mellitus. Management of diabetes mellitus involves drug therapy to normalize blood glucose levels, monitoring for and treating any complications related to diabetes, and modifying any other risk factors for other conditions such as cardiovascular disease. The first-line drug for the vast majority of patients with type 2 diabetes mellitus is metformin, with second-line drugs including sulfonylureas, gliptins, and pioglitazone. Insulin is used if oral medication is not controlling the blood glucose to a sufficient degree.
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This question is part of the following fields:
- Endocrine System
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Question 8
Correct
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A 42-year-old man with schizophrenia undergoes his yearly physical examination. He is currently taking risperidone as part of his medication regimen.
What is the most common issue that can be linked to the use of risperidone in this patient?Your Answer: Galactorrhoea
Explanation:Risperidone, an atypical antipsychotic, has the potential to increase prolactin levels. This is because it inhibits dopamine, which reduces dopamine-mediated inhibition of prolactin. Although elevated prolactin may not cause any symptoms, it can have adverse effects if persistently elevated. One of the major roles of prolactin is to stimulate milk production in the mammary glands. Therefore, any cause of raised prolactin can result in milk production, which is known as galactorrhoea. This can occur in both males and females due to raised prolactin levels. Galactorrhoea is the most likely side effect caused by risperidone.
Raised prolactin levels can also lead to reduced libido and infertility in both sexes. However, it is unlikely to result in increased libido. Prolactin can interfere with other hormones, such as oestrogen and progesterone, which can cause irregular periods, but it does not specifically cause painful periods. Elevated levels of prolactin would not result in seizures. Risperidone is more likely to be associated with weight gain rather than weight loss, as it acts on the histamine receptor.
Understanding Prolactin and Its Functions
Prolactin is a hormone that is produced by the anterior pituitary gland. Its primary function is to stimulate breast development and milk production in females. During pregnancy, prolactin levels increase to support the growth and development of the mammary glands. It also plays a role in reducing the pulsatility of gonadotropin-releasing hormone (GnRH) at the hypothalamic level, which can block the action of luteinizing hormone (LH) on the ovaries or testes.
The secretion of prolactin is regulated by dopamine, which constantly inhibits its release. However, certain factors can increase or decrease prolactin secretion. For example, prolactin levels increase during pregnancy, in response to estrogen, and during breastfeeding. Additionally, stress, sleep, and certain drugs like metoclopramide and antipsychotics can also increase prolactin secretion. On the other hand, dopamine and dopaminergic agonists can decrease prolactin secretion.
Overall, understanding the functions and regulation of prolactin is important for reproductive health and lactation.
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This question is part of the following fields:
- Endocrine System
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Question 9
Correct
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What is the association between brown tumours of bone and a specific condition or disease?
Your Answer: Hyperparathyroidism
Explanation:Brown tumors are bone tumors that develop due to excessive osteoclast activity, typically in cases of hyperparathyroidism. These tumors are composed of fibrous tissue, woven bone, and supporting blood vessels, but lack any matrix. They do not appear on x-rays due to their radiolucent nature. Osteoclasts consume the trabecular bone that osteoblasts produce, leading to a cycle of reparative bone deposition and resorption that can cause bone pain and involve the periosteum, resulting in an expansion beyond the typical shape of the bone. The tumors are called brown due to the deposition of haemosiderin at the site.
Primary Hyperparathyroidism: Causes, Symptoms, and Treatment
Primary hyperparathyroidism is a condition that is commonly seen in elderly females and is characterized by an unquenchable thirst and an inappropriately normal or raised parathyroid hormone level. It is usually caused by a solitary adenoma, hyperplasia, multiple adenoma, or carcinoma. While around 80% of patients are asymptomatic, the symptomatic features of primary hyperparathyroidism may include polydipsia, polyuria, depression, anorexia, nausea, constipation, peptic ulceration, pancreatitis, bone pain/fracture, renal stones, and hypertension.
Primary hyperparathyroidism is associated with hypertension and multiple endocrine neoplasia, such as MEN I and II. To diagnose this condition, doctors may perform a technetium-MIBI subtraction scan or look for a characteristic X-ray finding of hyperparathyroidism called the pepperpot skull.
The definitive management for primary hyperparathyroidism is total parathyroidectomy. However, conservative management may be offered if the calcium level is less than 0.25 mmol/L above the upper limit of normal, the patient is over 50 years old, and there is no evidence of end-organ damage. Patients who are not suitable for surgery may be treated with cinacalcet, a calcimimetic that mimics the action of calcium on tissues by allosteric activation of the calcium-sensing receptor.
In summary, primary hyperparathyroidism is a condition that can cause various symptoms and is commonly seen in elderly females. It can be diagnosed through various tests and managed through surgery or medication.
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This question is part of the following fields:
- Endocrine System
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Question 10
Incorrect
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A 60-year-old patient visits their doctor complaining of dehydration caused by vomiting and diarrhoea. The kidneys detect reduced renal perfusion, leading to activation of the renin-angiotensin-aldosterone system. What is the specific part of the adrenal gland required for this system?
Your Answer: Juxtaglomerular cells
Correct Answer: Zona glomerulosa
Explanation:Aldosterone is produced in the zona glomerulosa of the adrenal gland.
Renin is released by juxtaglomerular cells located in the nephron.
ACE is produced by the pulmonary endothelium in the lungs.
The adrenal gland is composed of the zona glomerulosa, fasciculata, and reticularis.
Glucocorticoids are produced in the zona fasciculata.
Adrenal Physiology: Medulla and Cortex
The adrenal gland is composed of two main parts: the medulla and the cortex. The medulla is responsible for secreting the catecholamines noradrenaline and adrenaline, which are released in response to sympathetic nervous system stimulation. The chromaffin cells of the medulla are innervated by the splanchnic nerves, and the release of these hormones is triggered by the secretion of acetylcholine from preganglionic sympathetic fibers. Phaeochromocytomas, which are tumors derived from chromaffin cells, can cause excessive secretion of both adrenaline and noradrenaline.
The adrenal cortex is divided into three distinct zones: the zona glomerulosa, zona fasciculata, and zona reticularis. Each zone is responsible for secreting different hormones. The outer zone, zona glomerulosa, secretes aldosterone, which regulates electrolyte balance and blood pressure. The middle zone, zona fasciculata, secretes glucocorticoids, which are involved in the regulation of metabolism, immune function, and stress response. The inner zone, zona reticularis, secretes androgens, which are involved in the development and maintenance of male sex characteristics.
Most of the hormones secreted by the adrenal cortex, including glucocorticoids and aldosterone, are bound to plasma proteins in the circulation. Glucocorticoids are inactivated and excreted by the liver. Understanding the physiology of the adrenal gland is important for the diagnosis and treatment of various endocrine disorders.
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This question is part of the following fields:
- Endocrine System
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Question 11
Correct
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A 65-year-old man with a history of type 2 diabetes is being seen by his primary care physician.
He is currently taking metformin 1g twice daily and lisinopril for his high blood pressure.
His most recent HbA1c result is:
HbA1c 58 mmol/L (<42)
After further discussion, he has agreed to add a second medication for his diabetes. He has been informed that potential side effects may include weight gain, hypoglycemia, and gastrointestinal issues.
What is the mechanism of action for this new medication?Your Answer: Binding to KATP channels on pancreatic beta cell membrane
Explanation:Sulfonylureas are a type of medication used to treat type 2 diabetes mellitus. They work by increasing the amount of insulin produced by the pancreas, but only if the beta cells in the pancreas are functioning properly. Sulfonylureas bind to a specific channel on the cell membrane of pancreatic beta cells, known as the ATP-dependent K+ channel (KATP).
While sulfonylureas can be effective in managing diabetes, they can also cause some adverse effects. The most common side effect is hypoglycemia, which is more likely to occur with long-acting preparations like chlorpropamide. Another common side effect is weight gain. However, there are also rarer side effects that can occur, such as hyponatremia (low sodium levels) due to inappropriate ADH secretion, bone marrow suppression, hepatotoxicity (liver damage), and peripheral neuropathy.
It is important to note that sulfonylureas should not be used during pregnancy or while breastfeeding.
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This question is part of the following fields:
- Endocrine System
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Question 12
Incorrect
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A 53-year-old male presents to an endocrinology clinic with recurring symptoms of painful fingers and hands that seem to be enlarging. He was previously diagnosed with acromegaly eight months ago and underwent transsphenoidal surgery six months ago to remove the pituitary adenoma responsible. During examination, his facial features appear rough, and his hands are large and spade-like. You opt to manage this patient's symptoms with medication and initiate a trial of octreotide.
What physiological function is linked to this medication?Your Answer: Stimulation of insulin secretion from the pancreas
Correct Answer: Inhibition of glucagon secretion from the pancreas
Explanation:Somatostatin analogues, such as octreotide, are used to treat acromegaly in patients who have not responded well to surgery. Somatostatin is a hormone that has various functions, including inhibiting the secretion of growth hormone from the anterior pituitary gland and insulin and glucagon from the pancreas. Therefore, the correct answer is that somatostatin inhibits the secretion of glucagon.
The secretion of ACTH by the pancreas is regulated by a negative feedback loop involving cortisol and corticotropin-releasing hormone (CRH). When blood cortisol levels decrease, CRH is secreted from the hypothalamus, which then stimulates the secretion of ACTH from the anterior pituitary gland.
Somatostatin analogues typically do not affect the secretion of aldosterone from the pancreas, which is primarily stimulated by angiotensin-II.
Somatostatin analogues inhibit the secretion of growth hormone from the anterior pituitary gland. The hormone responsible for stimulating the secretion of growth hormone is growth hormone-releasing hormone (GHRH).
The secretion of insulin by pancreatic β-cells is inhibited by somatostatin analogues. The primary stimulus for insulin secretion is low blood glucose levels, but other substances such as arginine and leucine, acetylcholine, sulfonylurea, cholecystokinin, and incretins can also stimulate insulin release.
Somatostatin: The Inhibitor Hormone
Somatostatin, also known as growth hormone inhibiting hormone (GHIH), is a hormone produced by delta cells found in the pancreas, pylorus, and duodenum. Its main function is to inhibit the secretion of growth hormone, insulin, and glucagon. It also decreases acid and pepsin secretion, as well as pancreatic enzyme secretion. Additionally, somatostatin inhibits the trophic effects of gastrin and stimulates gastric mucous production.
Somatostatin analogs are commonly used in the management of acromegaly, a condition characterized by excessive growth hormone secretion. These analogs work by inhibiting growth hormone secretion, thereby reducing the symptoms associated with acromegaly.
The secretion of somatostatin is regulated by various factors. Its secretion increases in response to fat, bile salts, and glucose in the intestinal lumen, as well as glucagon. On the other hand, insulin decreases the secretion of somatostatin.
In summary, somatostatin plays a crucial role in regulating the secretion of various hormones and enzymes in the body. Its inhibitory effects on growth hormone, insulin, and glucagon make it an important hormone in the management of certain medical conditions.
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This question is part of the following fields:
- Endocrine System
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Question 13
Correct
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A 25-year-old woman has a total thyroidectomy to treat papillary carcinoma of the thyroid. During examination of histological sections of the thyroid gland, the pathologist discovers the presence of psammoma bodies. What is the primary composition of these bodies?
Your Answer: Clusters of calcification
Explanation:Clusters of microcalcification, known as psammoma bodies, are frequently observed in papillary carcinomas.
Thyroid cancer rarely causes hyperthyroidism or hypothyroidism as it does not usually secrete thyroid hormones. The most common type of thyroid cancer is papillary carcinoma, which is often found in young females and has an excellent prognosis. Follicular carcinoma is less common, while medullary carcinoma is a cancer of the parafollicular cells that secrete calcitonin and is associated with multiple endocrine neoplasia type 2. Anaplastic carcinoma is rare and not responsive to treatment, causing pressure symptoms. Lymphoma is also rare and associated with Hashimoto’s thyroiditis.
Management of papillary and follicular cancer involves a total thyroidectomy followed by radioiodine to kill residual cells. Yearly thyroglobulin levels are monitored to detect early recurrent disease. Papillary carcinoma usually contains a mixture of papillary and colloidal filled follicles, while follicular adenoma presents as a solitary thyroid nodule and malignancy can only be excluded on formal histological assessment. Follicular carcinoma may appear macroscopically encapsulated, but microscopically capsular invasion is seen. Medullary carcinoma is associated with raised serum calcitonin levels and familial genetic disease in up to 20% of cases. Anaplastic carcinoma is most common in elderly females and is treated by resection where possible, with palliation achieved through isthmusectomy and radiotherapy. Chemotherapy is ineffective.
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This question is part of the following fields:
- Endocrine System
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Question 14
Correct
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A 70-year-old male has been diagnosed with polymyalgia rheumatica and prescribed prednisolone. What is the most likely adverse effect he may experience?
Your Answer: Hyperglycaemia
Explanation:Hyperglycemia is the correct answer. Most patients who take steroids experience an increase in appetite and weight gain, so anorexia or weight loss are not appropriate responses.
Steroid hormones can also affect the aldosterone receptor in the collecting duct, potentially leading to hyponatremia.
Although changes in vision are possible due to steroid-induced cataracts, they are much less common.
High levels of non-endogenous steroids have several risk factors, including hyperglycemia, high blood pressure, obesity (particularly around the waist), muscle wasting, poor wound healing, and mood swings or depression.
Corticosteroids are commonly prescribed medications that can be taken orally or intravenously, or applied topically. They mimic the effects of natural steroids in the body and can be used to replace or supplement them. However, the use of corticosteroids is limited by their numerous side effects, which are more common with prolonged and systemic use. These side effects can affect various systems in the body, including the endocrine, musculoskeletal, gastrointestinal, ophthalmic, and psychiatric systems. Some of the most common side effects include impaired glucose regulation, weight gain, osteoporosis, and increased susceptibility to infections. Patients on long-term corticosteroids should have their doses adjusted during intercurrent illness, and the medication should not be abruptly withdrawn to avoid an Addisonian crisis. Gradual withdrawal is recommended for patients who have received high doses or prolonged treatment.
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This question is part of the following fields:
- Endocrine System
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Question 15
Correct
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A 25-year-old woman presents to the endocrinology clinic with a diagnosis of Grave's disease. The diagnosis was made based on her elevated levels of thyroid hormones T3 and T4, as well as symptoms of heat intolerance, weight loss, and tremors. Typically, where are the receptors for thyroid hormones found?
Your Answer: Nucleus
Explanation:Thyroid hormones can enter cells through diffusion or carriers. Once inside, they bind to intracellular DNA-binding proteins called thyroid hormone receptors located in the nucleus. This binding forms a complex that attaches to the thyroid hormone responsive element on DNA. The outcome of this process is an increase in mRNA production, protein synthesis, Na/K ATPase, mitochondrial function leading to higher oxygen consumption, and adrenoceptors.
Thyroid disorders are commonly encountered in clinical practice, with hypothyroidism and thyrotoxicosis being the most prevalent. Women are ten times more likely to develop these conditions than men. The thyroid gland is a bi-lobed structure located in the anterior neck and is part of a hypothalamus-pituitary-end organ system that regulates the production of thyroxine and triiodothyronine hormones. These hormones help regulate energy sources, protein synthesis, and the body’s sensitivity to other hormones. Hypothyroidism can be primary or secondary, while thyrotoxicosis is mostly primary. Autoimmunity is the leading cause of thyroid problems in the developed world.
Thyroid disorders can present in various ways, with symptoms often being the opposite depending on whether the thyroid gland is under or overactive. For example, hypothyroidism may result in weight gain, while thyrotoxicosis leads to weight loss. Thyroid function tests are the primary investigation for diagnosing thyroid disorders. These tests primarily look at serum TSH and T4 levels, with T3 being measured in specific cases. TSH levels are more sensitive than T4 levels for monitoring patients with existing thyroid problems.
Treatment for thyroid disorders depends on the cause. Patients with hypothyroidism are given levothyroxine to replace the underlying deficiency. Patients with thyrotoxicosis may be treated with propranolol to control symptoms such as tremors, carbimazole to reduce thyroid hormone production, or radioiodine treatment.
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This question is part of the following fields:
- Endocrine System
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Question 16
Correct
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A 9-year-old girl is being treated by a paediatrician for bedwetting at night. Non-invasive methods have not yielded any results and her family is interested in trying medication. The paediatrician has approved a trial of desmopressin.
What is the site of action of this drug?Your Answer: The collecting ducts of the kidney
Explanation:Desmopressin is a synthetic version of antidiuretic hormone (ADH) that acts on the collecting ducts in the kidneys. ADH is released by the posterior pituitary gland in response to increased blood osmolality. By increasing the reabsorption of solute-free water in the collecting ducts, ADH reduces blood osmolality and produces small volumes of concentrated urine. This mechanism is effective in reducing the volume of urine produced overnight in cases of nocturnal enuresis (bed-wetting). The distal tubule, glomerulus, and proximal tubule are not sites of ADH action. Although the posterior pituitary gland produces ADH, it exerts its effects on the kidneys.
Understanding Antidiuretic Hormone (ADH)
Antidiuretic hormone (ADH) is a hormone that is produced in the supraoptic nuclei of the hypothalamus and released by the posterior pituitary gland. Its primary function is to conserve body water by promoting water reabsorption in the collecting ducts of the kidneys through the insertion of aquaporin-2 channels.
ADH secretion is regulated by various factors. An increase in extracellular fluid osmolality, a decrease in volume or pressure, and the presence of angiotensin II can all increase ADH secretion. Conversely, a decrease in extracellular fluid osmolality, an increase in volume, a decrease in temperature, or the absence of ADH can decrease its secretion.
Diabetes insipidus (DI) is a condition that occurs when there is either a deficiency of ADH (cranial DI) or an insensitivity to ADH (nephrogenic DI). Cranial DI can be treated with desmopressin, which is an analog of ADH.
Overall, understanding the role of ADH in regulating water balance in the body is crucial for maintaining proper hydration and preventing conditions like DI.
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This question is part of the following fields:
- Endocrine System
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Question 17
Correct
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A 20-year-old man comes to the emergency department complaining of abdominal pain, vomiting, polyuria, polydipsia, and confusion that have been present for the past 12 hours. During the examination, he shows mild generalized abdominal tenderness without guarding. His breathing is observed to be deep and rapid.
The patient has a medical history of type 1 diabetes, but he confesses to being non-compliant with his insulin regimen.
What is the probable pathophysiology behind his symptoms?Your Answer: Uncontrolled lipolysis which results in an excess of free fatty acids
Explanation:The cause of DKA is uncontrolled lipolysis, leading to an excess of free fatty acids that are converted to ketone bodies. This results in high levels of ketones in the urine. Hypoglycemia activates the sympathetic nervous system. Lactic acidosis is similar to DKA but lacks the presence of ketones in urine. Appendicitis can cause abdominal pain, vomiting, and urinary symptoms, but the presence of ketones in urine suggests DKA. Urinary tract infections are rare in men under 50 and typically occur with abnormal anatomy or catheterization.
Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes mellitus, accounting for around 6% of cases. It can also occur in rare cases of extreme stress in patients with type 2 diabetes mellitus. DKA is caused by uncontrolled lipolysis, resulting in an excess of free fatty acids that are converted to ketone bodies. The most common precipitating factors of DKA are infection, missed insulin doses, and myocardial infarction. Symptoms include abdominal pain, polyuria, polydipsia, dehydration, Kussmaul respiration, and breath that smells like acetone. Diagnostic criteria include glucose levels above 11 mmol/l or known diabetes mellitus, pH below 7.3, bicarbonate below 15 mmol/l, and ketones above 3 mmol/l or urine ketones ++ on dipstick.
Management of DKA involves fluid replacement, insulin, and correction of electrolyte disturbance. Fluid replacement is necessary as most patients with DKA are deplete around 5-8 litres. Isotonic saline is used initially, even if the patient is severely acidotic. Insulin is administered through an intravenous infusion, and correction of electrolyte disturbance is necessary. Long-acting insulin should be continued, while short-acting insulin should be stopped. Complications may occur from DKA itself or the treatment, such as gastric stasis, thromboembolism, arrhythmias, acute respiratory distress syndrome, acute kidney injury, and cerebral edema. Children and young adults are particularly vulnerable to cerebral edema following fluid resuscitation in DKA and often need 1:1 nursing to monitor neuro-observations, headache, irritability, visual disturbance, focal neurology, etc.
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This question is part of the following fields:
- Endocrine System
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Question 18
Correct
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An aged woman with malabsorption and weight loss was diagnosed with small bowel amyloidosis. She was initially found to have osteomalacia and hypocalcemia. Despite receiving total parenteral nutrition with sufficient calcium replacement for the past seven days, she remained hypocalcemic. Which electrolyte deficiency is most likely responsible for this condition?
Your Answer: Magnesium
Explanation:Magnesium deficiency may occur in patients with malabsorption, even if they receive magnesium through TPN feeds, as it may not be enough to compensate for their losses. Serum calcium levels are not affected by sodium, phosphate, and potassium.
The Importance of Magnesium and Calcium in the Body
Magnesium and calcium are essential minerals in the body. Magnesium plays a crucial role in the secretion and action of parathyroid hormone (PTH) on target tissues. However, a deficiency in magnesium can cause hypocalcaemia and make patients unresponsive to calcium and vitamin D supplementation.
The body contains 1000 mmol of magnesium, with half stored in bones and the rest in muscle, soft tissues, and extracellular fluid. Unlike calcium, there is no specific hormonal control of magnesium. Hormones such as PTH and aldosterone affect the renal handling of magnesium.
Magnesium and calcium also interact at a cellular level. A decrease in magnesium levels can affect the permeability of cellular membranes to calcium, leading to hyperexcitability. Therefore, it is essential to maintain adequate levels of both magnesium and calcium in the body for optimal health.
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This question is part of the following fields:
- Endocrine System
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Question 19
Correct
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A 25-year-old woman visits the endocrinology department for weight management issues. She has been struggling with her weight since she was a child and currently has a BMI of 46 kg/m². Despite eating large portions at meals, she never feels full and snacks between meals. Her parents and two older siblings are all at a healthy weight. Genetic testing reveals a de novo mutation in the satiety signalling pathway. Which hormone's decreased synthesis may be responsible for her condition?
Your Answer: Leptin
Explanation:Leptin is the hormone that lowers appetite, while ghrelin is the hormone that increases appetite. Leptin is produced by adipose tissue and plays a crucial role in regulating feelings of fullness and satiety. Mutations that affect leptin signaling can lead to severe childhood-onset obesity. On the other hand, ghrelin is known as the hunger hormone and stimulates appetite. However, decreased ghrelin synthesis does not cause obesity. Insulin is an anabolic hormone that promotes glucose uptake and lipogenesis, while obestatin’s role in satiety is still controversial.
The Physiology of Obesity: Leptin and Ghrelin
Leptin is a hormone produced by adipose tissue that plays a crucial role in regulating body weight. It acts on the hypothalamus, specifically on the satiety centers, to decrease appetite and induce feelings of fullness. In cases of obesity, where there is an excess of adipose tissue, leptin levels are high. Leptin also stimulates the release of melanocyte-stimulating hormone (MSH) and corticotrophin-releasing hormone (CRH), which further contribute to the regulation of appetite. On the other hand, low levels of leptin stimulate the release of neuropeptide Y (NPY), which increases appetite.
Ghrelin, on the other hand, is a hormone that stimulates hunger. It is mainly produced by the P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas. Ghrelin levels increase before meals, signaling the body to prepare for food intake, and decrease after meals, indicating that the body has received enough nutrients.
In summary, the balance between leptin and ghrelin plays a crucial role in regulating appetite and body weight. In cases of obesity, there is an imbalance in this system, with high levels of leptin and potentially disrupted ghrelin signaling, leading to increased appetite and weight gain.
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This question is part of the following fields:
- Endocrine System
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Question 20
Correct
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A 65-year-old man presents to the Emergency Department with confusion, drowsiness, and nausea accompanied by vomiting. His daughter reports that he has been feeling fatigued and unwell with a persistent cough, and he has been smoking 20 cigarettes per day for 45 years. The patient is unable to provide a complete medical history due to his confusion, but he mentions that he sometimes coughs up blood and his urine has been darker than usual. On examination, he appears to be short of breath but euvolaemic. Blood tests reveal low serum sodium, high urinary sodium, low plasma osmolality, and high urinary osmolality. Renal and thyroid function tests are normal. A chest x-ray shows a lung carcinoma, leading you to suspect that this presentation may be caused by a syndrome of inappropriate antidiuretic hormone secretion.
What is the underlying mechanism responsible for the hyponatraemia?Your Answer: Insertion of aquaporin-2 channels
Explanation:The insertion of aquaporin-2 channels is promoted by antidiuretic hormone, which facilitates water reabsorption. However, in the case of syndrome of inappropriate antidiuretic hormone secretion (SiADH), which is caused by small cell lung cancer, the normal negative feedback loop fails, resulting in the continuous production of ADH even when serum osmolality returns to normal. This leads to euvolemic hyponatremia, where the body retains water but continues to lose sodium, resulting in concentrated urine. The underlying mechanism of this condition is the persistent increase in the number of aquaporin-2 channels, which promotes water reabsorption, rather than any effect on sodium transport mechanisms.
Understanding Antidiuretic Hormone (ADH)
Antidiuretic hormone (ADH) is a hormone that is produced in the supraoptic nuclei of the hypothalamus and released by the posterior pituitary gland. Its primary function is to conserve body water by promoting water reabsorption in the collecting ducts of the kidneys through the insertion of aquaporin-2 channels.
ADH secretion is regulated by various factors. An increase in extracellular fluid osmolality, a decrease in volume or pressure, and the presence of angiotensin II can all increase ADH secretion. Conversely, a decrease in extracellular fluid osmolality, an increase in volume, a decrease in temperature, or the absence of ADH can decrease its secretion.
Diabetes insipidus (DI) is a condition that occurs when there is either a deficiency of ADH (cranial DI) or an insensitivity to ADH (nephrogenic DI). Cranial DI can be treated with desmopressin, which is an analog of ADH.
Overall, understanding the role of ADH in regulating water balance in the body is crucial for maintaining proper hydration and preventing conditions like DI.
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This question is part of the following fields:
- Endocrine System
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Question 21
Incorrect
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A patient with a recent diagnosis of schizophrenia at the age of 40 is prescribed risperidone. During their consultation with the doctor, they are informed that some of the potential side effects are caused by elevated levels of prolactin.
What is the mechanism behind this occurrence?Your Answer: Stimulation of dopamine activity
Correct Answer: Inhibition of dopamine activity
Explanation:Dopamine plays a crucial role in inhibiting the release of prolactin. As atypical antipsychotics like risperidone block dopamine activity, they can lead to increased levels of prolactin. While these drugs may also inhibit histamine and serotonin to varying degrees, it is the inhibition of dopamine that is directly linked to prolactin release. Stimulation of dopamine or serotonin activity would not interfere with prolactin release in the same way that dopamine inhibition does.
Understanding Prolactin and Its Functions
Prolactin is a hormone that is produced by the anterior pituitary gland. Its primary function is to stimulate breast development and milk production in females. During pregnancy, prolactin levels increase to support the growth and development of the mammary glands. It also plays a role in reducing the pulsatility of gonadotropin-releasing hormone (GnRH) at the hypothalamic level, which can block the action of luteinizing hormone (LH) on the ovaries or testes.
The secretion of prolactin is regulated by dopamine, which constantly inhibits its release. However, certain factors can increase or decrease prolactin secretion. For example, prolactin levels increase during pregnancy, in response to estrogen, and during breastfeeding. Additionally, stress, sleep, and certain drugs like metoclopramide and antipsychotics can also increase prolactin secretion. On the other hand, dopamine and dopaminergic agonists can decrease prolactin secretion.
Overall, understanding the functions and regulation of prolactin is important for reproductive health and lactation.
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This question is part of the following fields:
- Endocrine System
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Question 22
Correct
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A 22-year-old male presents to the emergency department with a two-hour history of nausea, confusion, and drowsiness. The patient has a medical history of type 1 diabetes mellitus.
Upon conducting an A-E examination, the only significant finding is a plasma glucose level of 3.4 mmol/L. The patient is capable of swallowing.
What is the most suitable course of action for managing this patient?Your Answer: Two tubes of oral glucose gel
Explanation:The recommended first-line treatment for a conscious patient with hypoglycaemia is a fast-acting carbohydrate taken orally, such as glucose liquids, tablets, or gels. In this case, the appropriate course of action would be to administer two tubes of glucose gel. Glucagon via intramuscular injection is not necessary unless the patient is experiencing severe hypoglycaemia or is unable to swallow. Insulin via intramuscular injection is not appropriate for treating hypoglycaemia, and intravenous glucose is only used in cases of severe hypoglycaemia.
Understanding Hypoglycaemia: Causes, Features, and Management
Hypoglycaemia is a condition characterized by low blood sugar levels, which can lead to a range of symptoms and complications. There are several possible causes of hypoglycaemia, including insulinoma, liver failure, Addison’s disease, and alcohol consumption. The physiological response to hypoglycaemia involves hormonal and sympathoadrenal responses, which can result in autonomic and neuroglycopenic symptoms. While blood glucose levels and symptom severity are not always correlated, common symptoms of hypoglycaemia include sweating, shaking, hunger, anxiety, nausea, weakness, vision changes, confusion, and dizziness. In severe cases, hypoglycaemia can lead to convulsions or coma.
Managing hypoglycaemia depends on the severity of the symptoms and the setting in which it occurs. In the community, individuals with diabetes who inject insulin may be advised to consume oral glucose or a quick-acting carbohydrate such as GlucoGel or Dextrogel. A ‘HypoKit’ containing glucagon may also be prescribed for home use. In a hospital setting, treatment may involve administering a quick-acting carbohydrate or subcutaneous/intramuscular injection of glucagon for unconscious or unable to swallow patients. Alternatively, intravenous glucose solution may be given through a large vein.
Overall, understanding the causes, features, and management of hypoglycaemia is crucial for individuals with diabetes or other conditions that increase the risk of low blood sugar levels. Prompt and appropriate treatment can help prevent complications and improve outcomes.
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This question is part of the following fields:
- Endocrine System
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Question 23
Correct
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The following results were obtained on a 57-year-old male who complains of fatigue:
Free T4 9.8 pmol/L (9.0-25.0)
TSH 50.02 mU/L (0.27-4.20)
What physical signs would you anticipate during the examination?Your Answer: Slow relaxation of tendon jerks
Explanation:Symptoms and Signs of Hypothyroidism
Hypothyroidism is a condition that is characterized by an underactive thyroid gland, which leads to a decrease in the production of thyroid hormones. This condition is associated with several symptoms and signs, including a relative bradycardia, slow relaxation of tendon jerks, pale complexion, thinning of the hair, and weight gain. In severe cases of hypothyroidism, hypothermia may also be present.
A relative bradycardia refers to a slower than normal heart rate, which is a common symptom of hypothyroidism. Additionally, slow relaxation of tendon jerks is another sign of this condition. This refers to a delay in the relaxation of muscles after a reflex is elicited. Other physical signs of hypothyroidism include a pale complexion and thinning of the hair, which can be attributed to a decrease in metabolic activity.
Weight gain is also a common symptom of hypothyroidism, as the decrease in thyroid hormone production can lead to a slower metabolism and decreased energy expenditure. In severe cases of hypothyroidism, hypothermia may also be present, which refers to a body temperature that is lower than normal.
It is important to note that while a thyroid bruit is typical of Graves’ thyrotoxicosis, it is not a common sign of hypothyroidism. Overall, the symptoms and signs of hypothyroidism can vary in severity and may require medical intervention to manage.
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This question is part of the following fields:
- Endocrine System
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Question 24
Correct
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A 25-year-old female visits her GP complaining of chronic thirst, polyuria, and nocturia that have persisted for 2 months. She has a medical history of premenstrual dysphoric disorder diagnosed 3 years ago. After a series of tests, the patient is diagnosed with primary polydipsia. What results are expected from her water deprivation test?
Your Answer: High urine osmolality after both fluid deprivation and desmopressin
Explanation:The patient has primary polydipsia, a psychogenic disorder causing excessive drinking despite being hydrated. Urine osmolality is high after both fluid deprivation and desmopressin, as the patient still produces and responds to ADH. Low urine osmolality after both fluid deprivation and desmopressin is typical of nephrogenic DI, while low urine osmolality after fluid deprivation but high after desmopressin is typical of cranial DI. Low urine osmolality after desmopressin and low urine osmolality after fluid deprivation but normal after desmopressin are not commonly seen with any pathological state.
The water deprivation test is a diagnostic tool used to assess patients with polydipsia, or excessive thirst. During the test, the patient is instructed to refrain from drinking water, and their bladder is emptied. Hourly measurements of urine and plasma osmolalities are taken to monitor changes in the body’s fluid balance. The results of the test can help identify the underlying cause of the patient’s polydipsia. Normal results show a high urine osmolality after the administration of DDAVP, while psychogenic polydipsia is characterized by a low urine osmolality. Cranial DI and nephrogenic DI are both associated with high plasma osmolalities and low urine osmolalities.
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This question is part of the following fields:
- Endocrine System
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Question 25
Correct
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Which one of the following is not associated with excessive glucocorticoids?
Your Answer: Hyponatraemia
Explanation:Excessive levels of glucocorticoids can lead to various negative consequences such as skin thinning, osteonecrosis, and osteoporosis. Steroids can cause the body to retain sodium and water, while also resulting in potassium loss and potentially leading to hypokalaemic alkalosis.
Cortisol: Functions and Regulation
Cortisol is a hormone produced in the zona fasciculata of the adrenal cortex. It plays a crucial role in various bodily functions and is essential for life. Cortisol increases blood pressure by up-regulating alpha-1 receptors on arterioles, allowing for a normal response to angiotensin II and catecholamines. However, it inhibits bone formation by decreasing osteoblasts, type 1 collagen, and absorption of calcium from the gut, while increasing osteoclastic activity. Cortisol also increases insulin resistance and metabolism by increasing gluconeogenesis, lipolysis, and proteolysis. It inhibits inflammatory and immune responses, but maintains the function of skeletal and cardiac muscle.
The regulation of cortisol secretion is controlled by the hypothalamic-pituitary-adrenal (HPA) axis. The pituitary gland secretes adrenocorticotropic hormone (ACTH), which stimulates the adrenal cortex to produce cortisol. The hypothalamus releases corticotrophin-releasing hormone (CRH), which stimulates the pituitary gland to release ACTH. Stress can also increase cortisol secretion.
Excess cortisol in the body can lead to Cushing’s syndrome, which can cause a range of symptoms such as weight gain, muscle weakness, and high blood pressure. Understanding the functions and regulation of cortisol is important for maintaining overall health and preventing hormonal imbalances.
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This question is part of the following fields:
- Endocrine System
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Question 26
Incorrect
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A father is concerned about his 14-month-old child who has been having up to 10 wet nappies a day. He recalls that his cousin had a kidney condition and wonders if it could be affecting his child. After being referred to a paediatrician, the doctor mentions the possibility of Bartter's syndrome.
What is the root cause of Bartter's syndrome?Your Answer: Mutated NCl symporter in the distal convoluted tubule
Correct Answer: Mutated NKCC2 channel in the ascending loop of Henle
Explanation:The cause of Bartter’s syndrome is a faulty NKCC2 channel located in the ascending loop of Henle.
Polydipsia, polyuria, and dehydration are common symptoms of Bartter’s syndrome, which is an inherited disorder resulting from mutated NKCC2 channels.
Gitelman syndrome is a related condition caused by a mutated NCl symporter.
Nephrogenic and central diabetes insipidus are characterized by mutated ADH receptors and a lack of ADH production, respectively.
Bartter’s syndrome is a genetic disorder that causes severe hypokalaemia due to a defect in the absorption of chloride at the Na+ K+ 2Cl- cotransporter in the ascending loop of Henle. This disorder is usually inherited in an autosomal recessive manner. Unlike other endocrine causes of hypokalaemia, such as Conn’s, Cushing’s, and Liddle’s syndrome, Bartter’s syndrome is associated with normotension. Loop diuretics work by inhibiting NKCC2, which is similar to the effects of Bartter’s syndrome. The symptoms of Bartter’s syndrome usually appear in childhood and include failure to thrive, polyuria, polydipsia, hypokalaemia, normotension, and weakness.
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This question is part of the following fields:
- Endocrine System
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Question 27
Correct
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A 49-year-old man visits the clinic with complaints of muscle cramps and constipation that have been present for a week. He appears to be in good health otherwise. Upon conducting a serum potassium test, you discover that his levels are below the normal range. Your next step is to determine the underlying cause of his hypokalaemia. Which of the following medical conditions is commonly linked to low potassium levels?
Your Answer: Cushing's syndrome
Explanation:Cushing’s syndrome is the correct answer as it causes excess cortisol which can exhibit mineralocorticoid activity and lead to hypokalaemia. The kidneys play a major role in maintaining potassium balance, but other factors such as insulin, catecholamines, and aldosterone also influence potassium levels. The other options listed (congenital adrenal hypoplasia, Addison’s, rhabdomyolysis, metabolic acidosis) all cause hyperkalaemia. Addison’s disease and adrenal hypoplasia result in mineralocorticoid deficiency, leading to hyperkalaemia. Acidosis and rhabdomyolysis also cause hyperkalaemia. Symptoms of hypokalaemia include fatigue, muscle weakness, myalgia, muscle cramps, constipation, hyporeflexia, and rarely paralysis.
Causes of Cushing’s Syndrome
Cushing’s syndrome is a condition that can be caused by both endogenous and exogenous factors. However, it is important to note that exogenous causes, such as the use of glucocorticoid therapy, are more common than endogenous ones. The condition can be classified into two categories: ACTH dependent and ACTH independent causes.
ACTH dependent causes of Cushing’s syndrome include Cushing’s disease, which is caused by a pituitary tumor secreting ACTH and producing adrenal hyperplasia. Ectopic ACTH production, which is caused by small cell lung cancer, is another ACTH dependent cause. On the other hand, ACTH independent causes include iatrogenic factors such as steroid use, adrenal adenoma, adrenal carcinoma, Carney complex, and micronodular adrenal dysplasia.
In some cases, a condition called Pseudo-Cushing’s can mimic Cushing’s syndrome. This is often caused by alcohol excess or severe depression and can cause false positive results in dexamethasone suppression tests or 24-hour urinary free cortisol tests. To differentiate between Cushing’s syndrome and Pseudo-Cushing’s, an insulin stress test may be used.
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This question is part of the following fields:
- Endocrine System
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Question 28
Correct
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A 47-year-old female has been diagnosed with Grave's disease, experiencing weight loss, heat intolerance, and a tremor that is affecting her job as a waitress. Despite being prescribed carbimazole, she is unhappy with the results after 3 days. What other medication options are available for symptom management?
Your Answer: Beta blockers
Explanation:To alleviate symptoms, beta blockers like propranolol can be used to block the sympathetic effects on the heart. Guanethidine can also be administered to reduce catecholamine release. Statins and calcium channel blockers are not effective in treating the patient’s symptoms. Although benzodiazepines have anxiolytic and sedative properties, they may not be the most suitable option in this case.
Graves’ Disease: Common Features and Unique Signs
Graves’ disease is the most frequent cause of thyrotoxicosis, which is commonly observed in women aged 30-50 years. The condition presents typical features of thyrotoxicosis, such as weight loss, palpitations, and heat intolerance. However, Graves’ disease also displays specific signs that are not present in other causes of thyrotoxicosis. These include eye signs, such as exophthalmos and ophthalmoplegia, as well as pretibial myxoedema and thyroid acropachy. The latter is a triad of digital clubbing, soft tissue swelling of the hands and feet, and periosteal new bone formation.
Graves’ disease is characterized by the presence of autoantibodies, including TSH receptor stimulating antibodies in 90% of patients and anti-thyroid peroxidase antibodies in 75% of patients. Thyroid scintigraphy reveals a diffuse, homogenous, and increased uptake of radioactive iodine. These features help distinguish Graves’ disease from other causes of thyrotoxicosis and aid in its diagnosis.
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This question is part of the following fields:
- Endocrine System
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Question 29
Correct
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A 28-year-old woman complains of amenorrhoea and galactorrhoea for the past six months. She has not been taking any medication and has been in good health otherwise. A pregnancy test has come back negative. What would be the most suitable investigation for this patient?
Your Answer: Prolactin concentration
Explanation:Galactorrhoea and Prolactinomas
Galactorrhoea is a condition where breast milk is secreted, commonly seen during pregnancy and the early postpartum period. However, if a pregnancy test is negative, it may indicate the presence of a prolactinoma. Prolactinomas are tumors that develop in the pituitary gland, which can be either small or large. These tumors cause symptoms such as menstrual disturbance, infertility, and galactorrhoea due to the secretion of prolactin. Macroprolactinomas can also cause visual field defects, headache, and hypopituitarism due to their mass effect on the pituitary gland. Women with prolactinomas tend to present early due to menstrual cycle and fertility issues, while men may present later.
The diagnosis of prolactinomas is made by measuring serum prolactin levels and performing MRI imaging of the pituitary gland. Serum prolactin levels are typically several thousand, with a reference range of less than 690 U/L. Elevated prolactin levels can also be caused by pregnancy and lactation, hypothyroidism, and certain medications such as antipsychotics, anti-depressants, and anti-convulsants.
The treatment for prolactinomas involves drugs such as bromocriptine or cabergoline, which work by inhibiting prolactin release through the dopamine system. These drugs can cause significant tumor shrinkage over several weeks and months of treatment. Patients are typically monitored with serum prolactin levels and MRI scans for several years while continuing the medication. Some patients may be able to stop the medication without any further issues, while others may experience a relapse and need to resume treatment.
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This question is part of the following fields:
- Endocrine System
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Question 30
Incorrect
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A 4-month-old boy is being evaluated for possible hypospadias. In boys with this condition, where is the urethral opening most commonly found?
Your Answer: On the proximal ventral surface of the penis
Correct Answer: On the distal ventral surface of the penis
Explanation:The anomaly is typically situated on the underside and frequently towards the end. Urethral openings found closer to the body are a known occurrence. Surgical removal of the foreskin may hinder the process of repairing the defect.
Understanding Hypospadias: A Congenital Abnormality of the Penis
Hypospadias is a congenital abnormality of the penis that affects approximately 3 out of 1,000 male infants. It is usually identified during the newborn baby check, but if missed, parents may notice an abnormal urine stream. This condition is characterized by a ventral urethral meatus, a hooded prepuce, and chordee in more severe forms. In some cases, the urethral meatus may open more proximally in the more severe variants, but 75% of the openings are distally located.
There appears to be a significant genetic element to hypospadias, with further male children having a risk of around 5-15%. While it most commonly occurs as an isolated disorder, associated conditions include cryptorchidism (present in 10%) and inguinal hernia.
Once hypospadias has been identified, infants should be referred to specialist services. Corrective surgery is typically performed when the child is around 12 months of age. It is essential that the child is not circumcised prior to the surgery as the foreskin may be used in the corrective procedure. In boys with very distal disease, no treatment may be needed.
Overall, understanding hypospadias is important for parents and healthcare providers to ensure proper management and treatment for affected infants.
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This question is part of the following fields:
- Endocrine System
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